Synthesis of deuterium-labeled moxifloxacin

The stable isotope-labeled moxifloxacin was required in the clinical pharmacokinetic studies. Starting from furo[3,4-b]pyridine-5, 7-dione, a seven-step synthesis for deuterium-labeled moxifloxacin was described, and deuteriums were incorporated in positions 14, 20 of pyrrolo ring of moxifloxacin. The stable labeled moxifloxacin provided an outstanding internal standard for metabolism process studies.