1,25(OH)2D3对宫颈癌作用的研究进展 The Research Progress of 1,25(OH)2D3 Effects on Cervical Cancer

宫颈癌是目前常见的妇科恶性肿瘤之一，近年来由于人乳头瘤病毒(HPV)感染率的上升、人类生存环境的不断恶化等原因，宫颈癌的发病率呈现快速增高趋势，早期宫颈癌多采用手术治疗，晚期患者多采用手术联合放化疗等治疗方案。但是目前临床上用的化疗药物多具有较严重的毒性，限制了其临床应用。因此寻找新的、副作用小的药物是肿瘤研究的方向之一。近年来研究发现1,25(OH)2D3具有明显的抗肿瘤作用，现将其抗肿瘤效应及在宫颈癌方面的应用作一综述，为宫颈恶性肿瘤的临床治疗提供新的思路和理论依据。 Cervical cancer is one of common gynecological malignancies. In recent years, due to the rise of human papillomavirus (HPV) infection rates, the worsening of the human environment and other reasons, the incidence of cervical cancer showed a rapid increasing trend. Early cervical cancer is usually treated by surgery, while patients of advanced disease use surgery combining with radiotherapy and chemotherapy and other treatment options. But the chemotherapy drugs currently used in clinical practice have more serious toxicity, limiting its clinical application. Therefore, the search for drugs of new and few side effects is one of the directions of cancer research. Recent studies have found that 1,25(OH)2D3 has significant anti-tumor effect, and now its anti-tumor effects in cervical cancer and its application are reviewed, to provide new ideas and theoretical basis for the clinical treatment of cervical cancer.