Abstract P066: Shot-term Exposure to Ambient Air Pollution and Circulating Biomarkers of Systemic Inflammation: The Framingham Heart Study

Introduction: Exposure to air pollution has been positively associated with systemic inflammation. However, few large scale studies were conducted in regions with low levels of air pollution. We therefore studied the associations of air pollution with systemic inflammation biomarkers among participants in the Framingham Offspring and Third Generation cohorts in Greater Boston area. Methods: We measured C-reactive protein (CRP), fibrinogen, interleukin 6 (IL6), and tumor necrosis factor receptor 2 (TNFR2) in 3943 participants living within 50 km of a central site monitor in Boston. We calculated the 1-, 2-, 3-, 5-, and 7-day moving averages of fine particulate matter (PM2.5), black carbon (BC), sulfate (SO42-), nitrogen oxides (NOx), and ozone (O3) prior to the exam visits. We used linear mixed effects models and linear regression models to evaluate repeated measures and cross-sectional associations respectively, adjusting for age, sex, individual and area level measures of socioeconomic position, lifestyl...