Measurement of seminal and serum plasma magnesium levels in premature ejaculation

Background: Magnesium (Mg2+) is one of the trace elements present in human semen. Although premature ejaculation (PE) has been linked to Mg2+ deficiency, its role and relationship with PE needs to be studied more. Objective: This study was designed to determine the relationship between PE and serum as well as seminal plasma Mg2+ levels. Methods: Two-hundred Egyptian males complaining of PE were enrolled in this study (Group 1). Their ages ranged from 24 to 38 years. Fifty married healthy men (age and sex matched) were enrolled as controls (Group 2). Seminal as well as serum Mg2+ levels were measured using atomic absorption spectrometer in both patients and controls. Result: We found that mean seminal plasma Mg2+ was significantly low in patients with PE (Group 1) with normal mean serum Mg2+ level, while the mean serum and seminal plasma Mg2+ in control group (Group 2) was normal. Conclusion: This study demonstrated that PE has a significant relationship with decreased seminal plasma Mg2+. This highlights a possible role of seminal Mg2+ in the pathophysiology of PE.