SARS-CoV-2 e gestação: uma revisão dos fatos./ SARS-CoV-2 and Pregnancy: A Review of the Facts.

OBJECTIVE: The present comprehensive review aims to show the full extent of what is known to date and provide a more thorough view on the effects of SARS-CoV2 in pregnancy METHODS: Between March 29 and May, 2020, the words COVID-19, SARS-CoV2, COVID-19 and pregnancy, SARS-CoV2 and pregnancy, and SARS and pregnancy were searched in the PubMed and Google Scholar databases;the guidelines from well-known societies and institutions (Royal College of Obstetricians and Gynaecologists [RCOG], American College of Obstetricians and Gynecologists [ACOG], International Society of Ultrasound in Obstetrics & Gynecology [ISUOG], Centers for Disease Control and Prevention [CDC], International Federation of Gynecology and Obstetrics [FIGO]) were also included CONCLUSION: The COVID-19 outbreak resulted in a pandemic with>3 3 million cases and 230 thousand deaths until May 2nd It is caused by the SARS-CoV2 virus and may lead to severe pulmonary infection and multi-organ failure Past experiences show that unique characteristics in pregnancy make pregnant women more susceptible to complications from viral infections Yet, this has not been reported with this new virus There are risk factors that seem to increase morbidity in pregnancy, such as obesity (body mass index [BMI]>35), asthma and cardiovascular disease Current reports describe an increased rate of preterm birth and C-section Vertical transmission is still a possibility, due to a few reported cases of neonatal positive real-time polymerase chain reaction (RT-PCR) in nasal swab, amniotic fluid, and positive immunoglobulin M (IgM) in neonatal blood Treatments must be weighed in with caution due to the lack of quality trials that prove their effectiveness and safety during pregnancy Medical staff must use personal protective equipment in handling SARS-CoV2 suspected or positive patients and be alert for respiratory decompensations OBJETIVO: A presente revisao detalhada busca fornecer dados objetivos para avaliar o que se sabe ate o momento e possibilitar uma visao mais ampla dos efeitos do SARS-CoV2 na gravidez MeTODOS: Entre 29 de marco e 2 de maio de 2020, foi realizada uma busca nos bancos de dados PubMed e Google Scholar com as palavras COVID-19, SARS-CoV2, COVID-19 e gravidez, SARS-CoV2 e gravidez, e SARS e gravidez As recomendacoes dos principais orgaos sobre o tema tambem foram acessadas CONCLUSaO: O surto de COVID-19 resultou em uma pandemia com>3 3 milhoes de casos e 230 mil mortes ate 2 de maio E uma condicao causada pelo virus SARS-CoV2 e pode levar ao acometimento pulmonar difuso e a falencia de multiplos orgaos Caracteristicas unicas da gestante tornam essa populacao mais propensas a complicacoes de infeccoes virais Ate o momento, essa tendencia nao foi observada para esse novo virus Os fatores que parecem estar associados a maior morbidade materno-fetal sao obesidade (indice de massa corporal [IMC]>35), asma e doenca cardiovascular Ha descricao de aumento de parto prematuro e parto cesareo Nao se pode descartar a possibilidade de transmissao vertical da doenca, devido a relatos de positividade de reacao em cadeia de polimerase (RT-PCR) de swab nasal, RT-PCR de liquido amniotico e imunoglobulina M (IgM) de recem-nascidos Tratamentos devem ser analisados caso a caso, dada a falta de qualidade de estudos que comprovem a sua eficacia e seguranca na gravidez O corpo clinico deve utilizar equipamentos de protecao individual (EPI) ao manusear pacientes suspeitos ou confirmados e ficar atento aos sinais de descompensacao respiratoria