Isolation and characterization of a human interleukin 2 gene

Abstract An interleukin 2 (IL-2) gene was isolated from a Charon 4A human gene library. Electron microscopic examination of 15 heteroduplexes formed between the genomic DNAs and the IL-2 cDNAs demonstrated that the size of the IL-2 gene is about 5.1 ± 0.5 kb and that there are at least two introns in this gene. Nucleotide sequence of the 5′ flanking region of the IL-2 gene showed a homology with that of the corresponding region of the human immune interferon gene.