N-(2-Dimethoxymethyl-3-hydroxy-2-methyl-6-nitro-3,4-dihydro-2H-1-benzopyran-4-yl)acetamide
1998
The benzopyran-based title compound, C 15 H 20 N 2 O 7 , is a potential potassium-channel opener with cardiovascular therapeutic activities. The 2-dimethoxymethyl and 3-hydroxyl groups are in axial positions while the 4-acetamide group is in a pseudo-equatorial position. The 4-acetamide group is nearly perpendicular to the benzopyran plane. There are two intermolecular hydrogen bonds; one between the hydroxyl O and acetamide O atoms [2.725 (5) A], and the other between the acetamide N and methoxy O atoms [3.139(5) A].
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