A method of preparing bazedoxifene acetate polymorphic b

The present invention discloses a method of preparing bazedoxifene acetate polymorphic form B of bazedoxifene free base in bar and acetic acid as starting material, to give a salt of bazedoxifene acetate polymorph form B. The present invention is simple preparation process conditions, without operating under inert gas protection, the manufacturing process without the addition of an antioxidant, the product produced a high yield and purity suitable for industrial production.