Ccr7 null mice are protected against diet-induced obesity via Ucp1 upregulation and enhanced energy expenditure
2019
Background
The chemokine receptor CCR7, expressed on various immune cells, is associated with cell migration and lympho-node homing. Mice lacking Ccr7 are protected from diet-induced obesity and subsequent insulin resistance. We evaluated the mechanism underlying these protective effects from the standpoint of energy expenditure.
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