Synthesis, in silico experiments and biological evaluation of 1,3,4-trisubstituted pyrazole derivatives as antimalarial agents

1,3,4 trisubstituted pyrazole derivative; 2 [3 (4 methoxyphenyl) 1 phenyl 1h pyrazol 4 yl] n phenyl 1,3,4 oxadiazol 5 amine; 2 [3 (4 methoxyphenyl) 1 phenyl 1h pyrazol 4 yl] n phenyl 1,3,4 thiadiazol 5 amine; 2 [3 (4 methoxyphenyl) 1 phenyl 1h pyrazole 4 carbonyl] n phenylhydrazinecarbothioamide; 3 (4 methoxyphenyl) 1 phenyl n' (3,4,5 trimethoxybenzylidene) 1h pyrazole 4 carbohydrazide; 3 (4 methoxyphenyl) 1 phenyl n' (pyridin 4 ylmethylene) 1h pyrazole 4 carbohydrazide; 3 (4 methoxyphenyl) 1 phenyl n' (thiophen 2 ylmethylene) 1h pyrazole 4 carbohydrazide; 3 (4 methoxyphenyl) n' (4 oxo 3 phenylthiazolidin 2 ylidene) 1 phenyl 1h pyrazole 4 carbohydrazide; 3 [3 (4 methoxyphenyl) 1 phenyl 1h pyrazol 4 yl] 4 phenyl 1h 1,2,4 triazole 5(4h) thione; 4 allyl 3 [3 (4 methoxyphenyl) 1 phenyl 1h pyrazol 4 yl] 1h 1,2,4 triazole 5(4h) thione; antiinflammatory agent; antimalarial agent; chloroquine; n allyl 2 [3 (4 methoxyphenyl) 1 phenyl 1h pyrazol 4 yl] 1,3,4 oxadiazol 5 amine; n allyl 2 [3 (4 methoxyphenyl) 1 phenyl 1h pyrazole 4 carbonyl]hydrazinecarbothioamide; n allyl 5 [3 (4 methoxyphenyl) 1 phenyl 1h pyrazol 4 yl] 1,3,4 thiadiazol 2 amine; n' (3 allyl 4 oxothiazolidin 2 ylidene) 3 (4 methoxyphenyl) 1 phenyl 1h pyrazole 4 carbohydrazide; n' (3 allyl 4 phenylthiazol 2(3h) ylidene) 3 (4 methoxyphenyl) 1 phenyl 1h pyrazole 4 carbohydrazide; n' (3 hydroxybenzylidene) 3 (4 methoxyphenyl) 1 phenyl 1h pyrazole 4 carbohydrazide; n' (3,4 diphenylthiazol 2(3h) ylidene) 3 (4 methoxyphenyl) 1 phenyl 1h pyrazole 4 carbohydrazide; n' (4 fluorobenzylidene) 3 (4 methoxyphenyl) 1 phenyl 1h pyrazole 4 carbohydrazide; n' benzylidene 3 (4 methoxyphenyl) 1 phenyl 1h pyrazole 4 carbohydrazide; n' [3 allyl 4 (4-bromophenyl)thiazol 2(3h) ylidene] 3 (4 methoxyphenyl) 1 phenyl 1h pyrazole 4 carbohydrazide; n' [4 (4 bromophenyl) 3 phenylthiazol 2(3h) ylidene] 3 (4 methoxyphenyl) 1 phenyl 1h pyrazole 4 carbohydrazide; pyrazole derivative; unclassified drug; animal experiment; animal model; antiinflammatory activity; antimalarial activity; Article; computer model; controlled study; cyclization; desulfurization; DNA synthesis; drug cytotoxicity; drug mechanism; drug potency; drug screening; drug synthesis; drug tolerability; erythrocyte; hemolysis assay; IC50; in vitro study; in vivo study; molecular docking; mouse; nonhuman; nucleophilicity; physical chemistry; Plasmodium berghei; Plasmodium falciparum; protonation; structure activity relation