Global denoising for 3D MRI

Background Denoising is the primary preprocessing step for subsequent application of MRI. However, most commonly-used patch-based denoising methods are heavily dependent on the degree of patch matching. Due to the large number of voxels in the 3D MRI dataset, the procedure of searching sufficient similarity patches was limited by the empirical compromising between computational efficiency and estimation accuracy, and cannot fulfill the application in multimodal MRI dataset with different SNR and resolutions.