The discovery of novel indole-2-carboxamides as cannabinoid CB1 receptor antagonists

Phillip Martin Cowley,James R. Baker,David R. Barn,Kirsteen Buchanan,Ian Carlyle,John K. Clark,Thomas R. Clarkson,Maureen Deehan,Darren Edwards,Richard Goodwin,David Robert Jaap,Yasuko Kiyoi,Chris Mort,Ronald Palin,Alan Prosser,Glenn Walker,Nick Ward,Grant Wishart,Trevor Young

The discovery of novel indole-2-carboxamides as cannabinoid CB1 receptor antagonists

2011

Phillip Martin Cowley
James R. Baker
David R. Barn
Kirsteen Buchanan
Ian Carlyle
John K. Clark
Thomas R. Clarkson
Maureen Deehan
Darren Edwards
Richard Goodwin
David Robert Jaap
Yasuko Kiyoi
Chris Mort
Ronald Palin
Alan Prosser
Glenn Walker
Nick Ward
Grant Wishart
Trevor Young

Abstract The discovery and structure–activity relationship of a novel series of indole-2-carboxamide antagonists of the cannabinoid CB 1 receptor is disclosed. Compound 26i was found to be a high potency, selective cannabinoid CB 1 antagonist.

Keywords:

Potency
Cannabinoid
Biochemistry
Indole test
Structure–activity relationship
Carboxamide
Receptor
Cannabinoid receptor
Chemistry
Pharmacology
Antagonist

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