Annexin V inhibits lipopolysaccharide-induced procoagulant activity on human monocytes

Induction of tissue factor expression on monocytes and endothelial cells is central in the development of septic coagulopathy. When stimulated by inflammatory agents such as endotoxin (lipopolysaccharide [LPS]) [1] and immune complex [2], peripheral blood monocytes generate procoagulant activity on their cell surfaces, resulting in activation of the coagulation cascade. This monocyte procoagulant activity has been shown to closely correlate with thromboembolic complications, local and general hypercoagulability in inflammation, and disseminated intravascular coagulation (DIC) [3]. DIC is a systemic thrombohemorrhagic disorder of diffuse activation of the clotting cascade that results in