High E/e′ disrupts the rapid lowering of blood glucose in response to exercise training

Background No relationship between the ratio of peak early velocity of left ventricular inflow to peak systolic longitudinal velocity of the mitral annulus velocity (E/e′) and insulin resistance has yet been shown in patients with cardiac disease. We hypothesized that patients with high E/e′ values would tend not to show the rapid blood glucose-lowering in response to exercise training characteristic of impaired glucose tolerance (IGT) or diabetes mellitus (DM) patients.