The synthesis and biological activity of 8-fluoro-9-(4-methyl-1-piperazinyl)-6-oxo-6H-benzo[c]quinolizine-5-carboxylic acid

A one-pot synthesis of ethyl 8,9-difluoro-6-oxo-6H-benzo[c]quinolizine-5-carboxylate 11 has been developed. The condensation of ethyl 2-pyridylacetate and 2,4,5-trifluorobenzoyl chloride followed by intramolecular nucleophilic aromatic substitution gave the desired ring system. This intermediate was converted to the title compound and its in vitro biological activity is reported.