Comparative study of efficacy and safety between two lipid emulsions used in parenteral nutrition

Introduction. The complications frequently associated with the use of lipid emulsions in parenteral nutrition include hypertriglyceridemia, and alterations in liver. Objective. The aim of this study was to compare the efficacy and safety between an olive oil-based fat emulsion and a multiple-source oil fat emulsion. Method. We performed a retrospective, observational study in a 600-bed general hospital. The study included 58 adult patients with individualized parenteral nutrition. 50% were administered a lipid emulsion composed of 80% olive oil and 20% soybean oil during three weeks administration in Parenteral Nutrition and another 50% a lipid emulsion composed of 30% soybean oil, 30% MCT, 25% olive oil and 15% ?sh oil during three weeks. Results. In the patients who were given lipid emulsion from multiple source, we observed an increase in the average value for the total plasma protein and for the albumin and a decrease in the average value of triglyceride, alanine transaminase, aspartate transaminase, gammaglutamyl transferase, alkaline phosphatase and total bilirubin. Conclusions. With the administration of the lipid emulsion from multiple source a reduction in triglyceridemia values and an improvement in liver function parameters is achieved, maintaining the caloric intake and improved nutrition parameters