Primary malignant melanoma of female urethra: a case report and review of literature

We report a very rare case report of female diagnosed with primary ma lignant melanoma. A 65 years old diabetic elderly postmenopausal female presented with a history of intermittent blood spots on undergarments for few days. Genital examination revealed a single, tan colored, soft chest nut size and polypoidal non ulcerated mass lesion protruding through the urethral meatus. Mass biopsy revealed poorly differentiated epithelial ma lignancy and immuno-histological analysis revealed positive with HMB 45 and protein S-100 suggestive of melanoma. Metastatic work up for the malignancy was negative. Complete urethrectomy with Mitrofanoff pro cedure with inguinal lymph node dissection was performed. Histopatho logical examination was suggestive of malignant melanoma of urethra. Here we discuss the clinicopathological features and management option possible in this scenario.