Real-time myocardial contrast echocardiography evaluates the effection of cardiac function on myocardial blood flow of acute myocardial infarction in mongrel

Objective:To investigate the effect of cardiac function on myocardial perfusion of the mongrel's acute myocardial infarction model.Method:Eighteen dogs were performed the acute myocardial infarction models by ligating the left anterior descending(LAD) 3 hours,then the contrast agent(C3F8) was injected into femoral vein to perform myocardial contrast echocardiography(MCE) examination,and quantitative calculate the myocardial blood flow(MBF) both of left ventricle middle-anterior wall and middle-posterior wall.Result:Seventeen dogs are successfully performed acute myocardial infraction models.Three hours after ligating LAD,in the A group(n=7) the eject fraction of left ventricle ≥50%,the MBF of middle-anterior wall is obviously lower than the one before ligating LAD(P0.01),but the MBF of middle-posterior wall is only a litter higher than that before ligating LAD(P0.05);in the B group(n=10) the eject fraction of left ventricle 50%,the MBF of middle-anterior wall is also obviously lower than the one before ligating LAD(P0.01),the MBF of middle-posterior wall is slightly lower than that before ligating LAD(P0.05);Between A group and B group after 3-hour ligating LAD,the MBF of both middle-anterior wall and middle-posterior wall in B group are only slightly lower than those in A group.Conclusion:The cardiac function can influence MBF sometines and maybe induce to undervalue the coronary reserve of flow and overmeasure the narrow degree of coronary,it's helpful to consider the cardiac function's effection using MCE to diagnosis coronary disease.