Submaximal isometric fatiguing exercise of the elbow flexors has no age-related effect on GABAB mediated inhibition.

Age-related changes in the neuromuscular system can result in differences in fatigability between young and older adults. Previous research has shown that single joint isometric fatiguing exercise of small muscle results in an age-related compensatory decrease in GABAB mediated inhibition. However, this has yet to be established in a larger muscle group. In 15 young (22 ± 4 years) and 15 older (65 ± 5 years) adults, long interval cortical inhibition (LICI; 100 ms ISI) and corticospinal silent period (SP) were measured in the biceps brachii during a 5% EMG contraction using transcranial magnetic stimulation (TMS) before, during and after a submaximal contraction (30% MVC force) held intermittently to task failure. Both age groups developed similar magnitude of fatigue (~24% decline in MVC; P = 0.001) and ~28% decline in LICI (P = 0.001) post fatiguing exercise. No change in SP duration was observed during and immediately following fatigue (P = 0.909) but ~ 6% decrease was seen at recovery in both age groups (P<0.001)." Contrary to previous work in a small muscle, these findings suggest no age-related differences in GABAB mediated inhibition following single joint isometric fatiguing exercise of the elbow flexors, indicating that GABAB modulation with ageing may be muscle group dependent. Furthermore, variations in SP duration and LICI modulation during and post fatigue in both groups suggest that these measures are likely mediated by divergent mechanisms.