COVID-19 and the Brain: Acute Encephalitis as a Clinical Manifestation

Central nervous system (CNS) viral infections result in the clinical syndromes of aseptic meningitis or encephalitis Although the primary target of coronavirus disease 2019 (COVID-19) is the respiratory system, it is increasingly being recognized as a neuropathogen The hallmark clinical feature is altered mental status, ranging from mild confusion to deep coma Most patients with encephalopathy or encephalitis are critically ill We present a case of COVID- 19-related encephalitis who presented with acute delirium and new-onset seizures The patient responded well to treatment with intravenous immunoglobulins and rituximab