Lower value of glycated haemoglobin relative to glycaemic control in diabetic patients with end-stage renal disease not on haemodialysis:

BackgroundGlycated haemoglobin (HbA1c) concentration is lower relative to glyacemic control in diabetic patients on haemodialysis. However, it is unknown as to whether this is also true for diabetic patients with end-stage renal disease but not on haemodialysis.MethodsCorrelations between HbA1c or glycated albumin (GA) and estimated glomerular filtration rate (eGFR) (determined by serum creatinine concentration, sex and age) were investigated in 86 diabetic patients with renal dysfunction not on dialysis. The mean values of HbA1c and of red blood cell (RBC) lifespan were compared among four groups of patients: Group 1 (n = 30, eGFR ≥ 60 mL/min/1.73 m2), Group 2 (n = 30, eGFR < 60 mL/min/1.73 m2 but ≥30 mL/min/1.73 m2), Group 3 (n = 13, eGFR < 30 mL/min/1.73 m2 but ≥15 mL/min/1.73 m2) and Group 4 (n = 13, eGFR < 15 mL/min/1.73 m2 without haemodialysis). RBC lifespan was determined in each subject from the difference between alveolar carbon monoxide (CO) concentration and atmospheric CO concentration.Result...