Fluorescent amyloid β-peptide ligand derivatives as potential diagnostic tools for Alzheimer’s disease

Aβ-peptide ligands based on a cis-glycofused benzopyran structure have been fluores cently labeled using coumarine derivatives. Among the synthesized compounds, two conserved their binding ability to β-amyloid peptides, as shown by NMR experiments. Moreover, exploiting its fluorescent property, it was demonstrated that one of such com- pounds was able to cross an in vitro model of blood-brain barrier (BBB) and to stain Aβ-deposits.