Chiral recognition of the angiotensin II (AT1) receptor by a highly potent phenoxyproline octanoamide

Mitchell I. Steinberg,Alan David Carmel Palkowitz,Kenneth Jeff Thrasher,Jon K. Reel,Karen Zimmerman,Celia A. Whitesitt,Richard Lee Simon,Kenneth Lee Hauser,Sherryl Lynn Lifer,William Pfeifer,Kumiko Takeuchi,Sally A. Wiest,Venkatraghavan Vasudevan,K.G. Bermis,Jack B. Deeter,Charles Jackson Barnett,Thomas Michael Wilson,Winston S. Marshall,Donald B. Boyd

Chiral recognition of the angiotensin II (AT1) receptor by a highly potent phenoxyproline octanoamide

1994

Mitchell I. Steinberg
Alan David Carmel Palkowitz
Kenneth Jeff Thrasher
Jon K. Reel
Karen Zimmerman
Celia A. Whitesitt
Richard Lee Simon
Kenneth Lee Hauser
Sherryl Lynn Lifer
William Pfeifer
Kumiko Takeuchi
Sally A. Wiest
Venkatraghavan Vasudevan
K.G. Bermis
Jack B. Deeter
Charles Jackson Barnett
Thomas Michael Wilson
Winston S. Marshall
Donald B. Boyd

Abstract The synthesis and in vitro biological evaluation of a novel series of diastereomeric phenoxyproline octanoamides ( 3–h ) as angiotensin II (AT 1 ) receptor antagonists are reported.

Keywords:

Diastereomer
Angiotensin II
Chemical synthesis
In vitro
Stereochemistry
Angiotensin II receptor type 1
Biochemistry
Biological activity
Chirality (chemistry)
Receptor
Chemistry

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