Inverse Relationship between Serum Metrnl Levels and Visceral Fat Obesity (VFO) in Patients with Type 2 Diabetes

Abstract Aim The relationship between serum Metrnl levels and visceral fat obesity (VFO) remains unclear. This study aimed to investigate the association between serum Metrnl levels and VFO in Chinese patients with type 2 diabetes. Methods A total of 321 Chinese patients with type 2 diabetes (226 men and 95 postmenopausal women aged 61.4±6.5 years, BMI 25.1±3.2kg/m2) were evaluated. Serum Metrnl levels were measured by enzyme linked-immunosorbent assay. Visceral fat area (VFA) was quantified via Dual Energy X-ray Absorptiometry (DXA). Correlation analyses were carried out for serum Metrnl levels and VFO. Results VFO groups(VFA ≧100cm2) have lower serum Metrnl levels than non-VFO groups(VFA Conclusions Serum Metrnl levels were inversely correlated with VFO and may be a useful indicator of VFO in Chinese patients with type 2 diabetes.