Companion Diagnosis for Retinal Neuroprotective Treatment by Real-Time Imaging of Calpain Activation Using a Novel Fluorescent Probe.

Toshifumi Asano,Yuri Nagayo,Satoru Tsuda,Azusa Ito,Wataru Kobayashi,Kosuke Fujita,Kota Sato,Koji M. Nishiguchi,Hiroshi Kunikata,Hiroyoshi Fujioka,Mako Kamiya,Yasuteru Urano,Toru Nakazawa

Companion Diagnosis for Retinal Neuroprotective Treatment by Real-Time Imaging of Calpain Activation Using a Novel Fluorescent Probe.

2020

Toshifumi Asano
Yuri Nagayo
Satoru Tsuda
Azusa Ito
Wataru Kobayashi
Kosuke Fujita
Kota Sato
Koji M. Nishiguchi
Hiroshi Kunikata
Hiroyoshi Fujioka
Mako Kamiya
Yasuteru Urano
Toru Nakazawa

Calpain activation induces retinal ganglion cell (RGC) death, while calpain inhibition suppresses RGC death, in animal studies. However, the role of calpain in human retinal disease is unclear. Thi...

Keywords:

Cell biology
Chemistry
Retinal ganglion cell
Retinal
Animal studies
Neuroprotection
Calpain
real time imaging
Fluorescence

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