Comparison of blood protein and target organ DNA and protein binding following topical application of benzo[a]pyrene and 7H-dibenzo[c,g]carbazole to mice

1994 
7H-Dibenzo[c,g]carbazole (DBC) induces skin and liver tumors in mice following topical application, whereas benzo[a]pyrene (BP) induces only skin tumors. DBC also binds to liver DNA to a much greater extent than does BP. The present study examined factors that might account for the difference in DNA binding activity. [ 3 H]DBC was applied topically to CD-1 mice at doses of 15, 100 and 1000 nmol/mouse and tissues and blood samples were taken 24 h later. Absorption of DBC from skin into blood and binding to blood proteins occurred linearly with dose. DBC bound to albumin at a 50-fold higher level than to globin and levels of albumin adducts showed good correlation with levels of DNA adducts in liver. Hepatic preference over skin in DNA binding was found to be dose-dependent
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