Long term management with medroxyprogesterone acetate in girls with true pubertas preacox

The article presents the case of 4 little girls aged 7-9 affected by true pubertas praecox with secondary sex characteristics menstruation and precocious skeletal growth. One of the girls was also affected by epilepsy and one by McCune-Albright syndrome. All girls were treated over a period of 2-5 years with injections of medroxyprogesterone acetate. Such treatment caused in all patients regression of mammary hypertrophy reduction of plasma gonadotropins and disappearance of menstruation. Skeletal growth was slowed down thus improving prognosis for final stature. Such results coincide with others published in the literature on the subject. (summary in ENG)