Toxicologic and Drug Metabolic Studies of SQ 14,225 in Animals

The historical development of SQ 14,225 as a potential therapeutic agent for the treatment of hypertension has been described by Cushman et al. and Rubin et al. in other chapters in this volume. This chapter will delineate the results of a number of studies that characterized the acute and subacute toxicities of SQ 14,225 in laboratory animals. Some metabolic data from preliminary studies in rats and dogs are also included.