Lack of adalimumab's complement dependent cytotoxicity on human cells expressing complement regulatory proteins.

It has been reported that upon binding to membrane TNF (mTNF), adalimumab may activate the complement system, leading to complement dependent cytotoxicity (CDC) of targeted cells. CDC has been implicated in mechanisms of action conferring adalimumab’s efficacy. CDC has also been proposed to contribute to the reactivation of opportunistic infections. CDC attributed to adalimumab in the U.S. product label refers to a mouse cell line transfected with a non-cleavable form of human TNF (SP2/0-11A5).