Body Fat and Fat Distribution by Anthropometry and the Response to High-Fat Cholesterol-Containing Diet in Monkeys

Abstract Considerable variability exists among individuals in the response of plasma cholesterol to changes in dietary fat and cholesterol, and obesity is one variable reported to affect this response. This study was performed to determine the relationship between body fat and changes in plasma cholesterol in cynomolgus monkeys fed a high-fat cholesterol-containing diet for 12 months. The animals gained significant body weight (body mass index increased from 30.5 ± 0.5 to 35.7 ± 2.8 kg/m 2 ) and skinfold parameters of body fat increased as well. Total cholesterol increased from 109 ± 4 to 390 ± 25 mg/dl ( P r ranged from -0.37 to -0.55, P