The role of C/EBP β in the inflammatory reaction mechanism of neurodegenerative diseases

To investigate the effect of C/EBP β on the neuroinflammation.Recently, neuroinflammation research mainly focused on C/EBP β, more and more researches indicated that C/EBP β may play an important role in neurodegenerative diseases.We searched the published papers in PubMed, CNKI, and Wan Fang date bases in June 2015.The key words were used as"CCAAT enhancer binding protein beta","Neuron","Neuroinflammation"and so on.According to the inclusion and exclusion criteria, we summaried and analyzed the literatures.Eventually, 42 articles were adapted, most of which were foused on the functions and mechanisms of C/EBP β in neuroinflammation.C/EBP β participate in multiple signaling pathways of neuroinflammation, and the regulation mechanism is complicated.Abrogation of C/EBP β expression or its downregulation by gene regulation may may serve as a therapeutic target to attenuate deleterious effects in neural tissue and ultimately prevent the development of neurodegenerative disorders. Key words: CCAAT/enhancer binding protein β; Neuron; Neuroinflammation