Comparison of Freelite™ and N Latex serum free light chain assays in subjects with end stage kidney disease on haemodialysis

Background: Quantification of serum free light chains (FLC) is important in the diagnosis of plasma cell diseases where an abnormal kappa: lambda ratio infers a population of monoclonal plasma cells. The Freelite (TM) and N Latex assays have been validated in populations without kidney disease but there is a paucity of data relating to the use of these assays in end stage kidney disease (ESKD). The aim of the study was to compare FLC assay performance in ESKD patients on haemodialysis.