Influence of antipsychotic treatment type and regimen on the functionality of patients with schizophrenia.

AbstractBackground: Enhanced functionality is a major goal in the treatment of schizophrenia. However, possible differences in the effectiveness of first- vs. second-generation antipsychotics or between depot/long-acting injectable (D/LAI) vs. D/LAI plus oral antipsychotics are not clear. Aims: This study was designed to evaluate possible differences between the effects of different antipsychotic treatment types or regimens on the functionality of patients with schizophrenia. Methods: 85 outpatients with schizophrenia, who were being treated with D/LAI antipsychotics— co-administered or not with oral antipsychotics—and had been adherent to the treatment during the previous year were evaluated. Socio-demographic, clinical, treatment-related, global severity and functionality variables were evaluated. Patients were grouped according to the type of antipsychotic drug (first- vs. second-generation) or according to the co-administration (or not) of oral antipsychotics. Results: No differences were found betwee...