Cytotoxic activities of ethyl acetate extract and a metabolite from a Monocillium species

The ethyl acetate soluble fraction of a cultural broth of a Monocillium species afforded the isolation of 5-hydroxymethylfurfural. Both the extract and 5-hydroxymethylfurfural showed significant cytotoxic activities in a brine shrimp bioassay and the LC50 values were found to be 14.96 µg/mL and 23.71 µg/mL, respectively. Copyright © 2005 John Wiley & Sons, Ltd.