MP32-07 BLADDER CANCER PATIENTS WITHOUT PATHOLOGIC RESPONSE TO NEOADJUVANT CHEMOTHERAPY EXPERIENCE LOWER SURVIVAL RATES THAN RADICAL CYSTECTOMY ALONE

INTRODUCTION AND OBJECTIVES:Approximately, 30-40% of bladder cancer patients treated with neoadjuvant chemotherapy (NAC) will have a pathologic complete response. Delayed radical cystectomy (RC) may compromise the outcome of patients not sensitive to NAC. The aim of our study was to compare overall survival (OS) between patients responsive and nonresponsive to NAC at time of RC to those who underwent RC alone.METHODS:The National Cancer Data Base was queried for patients who underwent RC with or without NAC for MIBC from 2004-2015. Covariates including age, sex, race, insurance, income, education, county, facility type, Charlson-Deyo comorbidity index, and clinical size (cT) were balanced using inverse probability of treatment weighting (IPTW). 6-month conditional landmark analyses, from the time of surgery, along with Cox proportional hazards models were conducted to analyze differences in OS. All models were stratified by pathological stage.RESULTS:11,287 were included in our analysis (Table 1). The 5-y...