ANTHROPOMETRIC MEASUREMENTS AND BODY COMPOSITIONS OF INDONESIAN PATIENTS WITH TYPE 2 DIABETES MELLITUS ARE ASSOCIATED WITH INFLAMMATION, INDEPENDENT OF SEX AND DISEASE DURATION

Introduction: Abnormal body composition, such as a high percentage of body fat, triggers an inflammatory reaction, which links the association between obesity and diabetes complications. Females, in general, have higher body fat, which may play a part in elevating cardiovascular disease risk. This study aimed to study the association between several anthropometric measurements and inflammatory markers in individuals with type 2 diabetes mellitus. We intended to confirm if this association is independent of sex and duration of diabetes. Material and Methods: People with type 2 diabetes mellitus were recruited from primary health care centers in Sleman, Indonesia. Several anthropometric measurements were performed, followed by an analysis of plasma high-sensitivity C-reactive protein. A comparison of anthropometric measurements was made between individuals with (high-sensitivity CRP<3 mg/L) and without inflammation (high-sensitivity CRP≥3mg/L). Spearman correlation analysis was conducted to learn the association between anthropometric measurements with the high- sensitivity CRP level. Adjustments were made for sex and duration of diabetes. Results: Differences were found on weight, BMI, hip circumference, upper-arm circumference, and wrist circumference. Among body composition measurements, total body fat, subcutaneous fat (whole body, trunk and leg), and visceral fat were different between groups. Bodyweight, BMI, waist circumference, hip circumference, arm circumference, neck circumference, and wrist circumference were significantly correlated with high-sensitivity CRP values. Conclusion: Associations were found between the inflammatory marker and anthropometric measurements, independent of sex and disease duration.