Effects of tetrocarcin-A on bovine theileriosis in Japan.

The effects of tetrocarcin-A (TC-A) in intravenous administration were studied in calves which had been infected, naturally or experimentally, with Theileria sergenti. The doses of the drug used were 0.32 to 6.4 mg/kg (body weight). No effect was detected when the drug was administered 3 times at a dose of 0.32 mg/kg. Prasitemia was decreased, but the level did not reach to negative even when 3 doses at 3.2 mg/kg were given. The drug was effective at a dose of 6.4 mg/kg and negative parasitemia was maintained for at least 10 days when the calf was given 2 administrations. The negative parasitemia was maintained for at least 32 days when the calf was given 3 doses.