Heberkinasa: recombinant streptokinase.

I would like to comment about Heberkinasa (recombinant streptokinase): one of the preparations included in the article written by Dr Hermentin et al. 1 The quality control system of the Center of Genetic Engineering and Biotechnology has been successfully evaluated by the World Health Organization and another International Regulatory Organizations. The biological activity of the Heberkinasa batch 80010 was approved by our quality control laboratory with a value of 688 773 IU, using the clot lysis assay described in the British Pharmacopoeia of 1998 for the determination of potency of streptokinase. A secondary standard of recombinant streptokinase previously calibrated against the Second International Standard for the streptokinase (code 88/826) was used. We participated in the International Collaborative Study organized by the NIBSC for the establishment of the Third International Standard for Streptokinase (laboratory number 4). Our results …