Effect of Donor Hepatic Steatosis on Ischemia Reperfusion Injury in Liver Transplant Recipient
2019
Abstract Introduction Ischemic reperfusion injury (IRI) is an important complication of liver transplant (LT). The donor risk index (DRI), which does not incorporate steatosis, includes several variables known to impact on allograft survival. The purpose of this study was to report on donor liver allograft steatosis and its association with severity of IRI. Aim To determine effect of type and grade of donor liver steatosis on the occurrence and severity of IRI in LT recipients. Methods This was an observational study done at single center over a period of 37 months from July 2013 to August 2016. Liver biopsy was done twice, initially at the time of procurement before graft perfusion for steatosis assessment. Steatosis was classified as micro (MiS) or macro (MaS) with mild, moderate or severe grade. Second biopsy for IRI assessment was taken before skin closure in death donor LT (DDLT) and at the time of transaminitis in postoperative period ( Results Among 53 subjects, 35 were DDLTs and 18 were LDLTs. All live donor grafts were restricted to Conclusion In patients with mild steatosis, IRI does not correlate with steatosis. However, more patients with moderate & severe steatosis are needed to define the relationship of the two in this group of patients.
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