Human antibodies activate complement against Plasmodium falciparum sporozoites, and are associated with protection against malaria in children
2018
Background
Antibodies targeting Plasmodium falciparum sporozoites play a key role in human immunity to malaria. However, antibody mechanisms that neutralize sporozoites are poorly understood. This has been a major constraint in developing highly efficacious vaccines, as we lack strong correlates of protective immunity.
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