Research values of interleukin-1 in tumor targeted therapies.

Members of interleukin-1 family are crucial proinflammatory cytokines,recent datas confirm that IL-1 family cytokines not only act as core mediators in regulating immunity and inflammatory reaction,but also play an important role in the development of tumor and tumor invasiveness.Anti-tumor strategides targeted on synthesis of IL-1 and IL-1 signal pathways,and the application of ICE inhibitor,NF-κB inhibitor and IL-Ra are evolving as promising methods in tumor therapy.