ASSOCIATION OF TRANSFORMING GROWTH FACTOR β1 GENE POLYMORPHISMS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN UYGHUR ETHNIC GROUP IN CHINA

[Objective] To study the relationship of transforming growth factor β1(TGF-β1) gene polymorphism and predisposition to chronic obstructive pulmonary disease(COPD) in Uyghur nationality in China.[Methods] The region of the TGF-β1 gene(869T/C and 915G/C) was studied in 75 Chinese Uygur patients with COPD and 153 normal controls by using allele-specific primer-polymerase chain reaction(ASP-PCR).[Results] The genotype distribution of +869T/C polymorphism in control subjects was as follows:TT,41.8%;CT,38.6% and CC,19.6%;and in COPD patients was as follows:TT,36.0%;CT,46.7% and CC,17.3%.The allele frequency of T and C was 61.1% and 38.9% in controls,59.3% and 40.7% in COPD patients.The genotype distribution of +915G/C polymorphism in control subjects was as follows:GG,81.7% ;GC,18.3% and CC,0.0%;and in COPD patients was as follows:GG,80.0%;GC,18.7% and CC,1.3%.The allele frequency of G and C was 90.8% and 9.2% in controls,89.3% and 10.7% in COPD patients.The distribution of genotypes at locus +869 and +915 was not significantly different between Chinese Uygur patients with COPD and controls(P﹥0.05),a significant difference in allele frequencies of +869 T/C and +915 G/C between Chinese Uyghur patients with COPD and control was not observed too(P﹥0.05).[Conclusion] The +869 and +915 SNPs of TGF-β1 gene might not be associated with the COPD susceptibility in Uyghur nationality in China.