Inhibition of thioacetamide-induced liver fibrosis by Piper nigrum Linn.

Piper nigrum Linn (Kalimirch) belonging to family Piperaceae is well known plant in ayrvedic and unani medicine. In the present study an attempt was made explore The anti fibrotic effect of ethonolic extract of this plant .Liver fibrosis was induced in the rats by thioacetamide orally 1ml/kg for 28 days. The extent of liver fibrosis was assessed by measuring the levels of liver hydroxyl proline (HP) Serum enzymes and total bilurubin (TBL) levels due to deposition of collagen .The liver weight of animals was increased following thioacetamide trated animals. And treated with Ethonolic extract of this plant reduced significantly the HP, Serum enzymes and SGOT, SGPTAnd TBL level and inhibited liver fibrosis induced by thioacetamide.