Se@Albumin nanoparticles ameliorate intestinal mucositis caused by cisplantin through the gut microbiota targeted regulation

Chemotherapy associated intestinal mucositis is still one of major challenge on the first-line clinical cancer treatment. Selenium element has been shown its health benefit on enteritis in trace uptake, however, which was limited because of its narrow safety. Here, a new form of Se@Albumin complex nanoparticles (Se@Albumin NPs) was developed by self-assembly of denatured human serum albumin and selenite salt. The Se@Albumin NPs significantly improves intestinal mucositis of mouse model with cisplantin (CDDP) induced through attenuating the level of intestinal oxidative stress, reducing intestinal permeability, and relieving gastric dysmotility. It is very interesting, the restoration of anti-inflammatory bacteria (Bacteroidetes, Firmicutes) and reduced abundance of proinflammatory bacteria (Escherichia) contributed to the Se@Albumin NPs reduce intestinal mucositis of mouse. And the fecal microbiota transplantation (FMT) with materials from Se@Albumin NPs-treated mice significantly protected pseudo-aseptic mice from CDDP induced intestinal mucositis. In conclusion, our findings showed that Se@Albumin NPs can significantly improve CDDP-induced intestinal mucositis, and its function may be directly mediated by the gut microbiota regulation, which will provide new helpful information for clinical treatment.