Synthesis and Pharmacological Evaluation of Some Novel 2-Mercapto Benzimidazole Derivatives

The present study is synthesis of derivatives of N'-(4-amino-5-sulfanyl-4H-1,2,4-triazole-3-yl)-2-(1H-benzimi- dazole-2-ylsulfanyl) acetohydrazide (IV). Antibacterial activity tested against the E. coli and A. Substilis. Biological activities conducted by disc diffusion method. Compound 2MB1, 2MB3, 2MB5 inhibit the appreciable microbial growth while rest of the compound possess the moderate activities. Anti-inflammatory activity tested by reduces local edema induced in the rat paw by injection of phlogestic agent. Compound 2MB1, 2MB8, 2MB5, 2MB3 and 2MB6 exhibit satisfying anti-inflammatory activity while analgesic activity conducted by acetic acid induced writhing effect in mice while compound 2MB1, 2MB4 and 2MB7 having the good analgesic activity. The chemical structures of all newly synthesized compounds were confirmed by their IR, 1 H NMR and mass spectral data.