Contributions of intestine and plasma to the presystemic bioconversion of vicagrel, an acetate of clopidogrel.
2014
Purpose
To investigate the contributions of intestine and plasma to the presystemic bioconversion of vicagrel, and track its subsequent bioconversion to 2-oxo-clopidogrel in vivo and in vitro to rationalize the design of vicagrel, an acetate analogue of clopidogrel.
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