Alport syndrome: gingival overgrowth caused by immunosuppressive therapy after renal transplatation.

Aim: The aim of this paper was to show periodontal treatment of rare systemic condition such as Alport syndrome. Material and Methods: A 35-year old male presented at Department of Periodontology complaining of tumor-like growth in last 6 months on gums above the upper left molar. Alport syndrome was diagnosed by genetic testing as Syndrome Epstein subtype with macrothrombocytopenia which was de novo mutation.The disease began as renal insufficiency at the age of 11 years. At the age of 26 he underwent a kidney transplantion (allotransplant, mother). Since then he is continuously taking immunosuppressive drugs. Clinical examination showed generalised hyperplasia of the papillae and soft tissue overgrowth of attached gingiva in pedicle like shape at the upper left second molar measuring 10x10 mm. Gingival overgrowth created pseudopockets. The mechanical therapy was performed and detailed instructions in oral hygiene were given. Chlorhexidine gluconate 0.2 % solution and azithromycin were prescribed. Results: Reevaluation after six weeks showed hyperplasia of the papillae significantly reduced on the molars and premolars, but growth on attached gingiva retained the size.