Synthetic methods of loxoprofen sodium and intermediate thereof

The invention discloses synthetic methods of loxoprofen sodium and an intermediate thereof; with benzene as a starting material, the key intermediate of loxoprofen sodium is obtained through acylation, halogenation, ketalation, rearrangement and Blanc chloromethylation, then the key intermediate is subjected to condensation, decarboxylation and salt forming reaction to obtain loxoprofen sodium. The methods have the advantages of easily obtained raw materials, simple operation, stable process and high yield; 2-(4-chloromethyl phenyl)propionic acid or propionate is prepared by adopting a method of direct carrying out chloromethylation on a substituted benzene ring, the operation is simple, the yield is high, the use of a chloromethyl ether reagent or stannic chloride and other Lewis acids is avoided, the environmental protection property is high, and relatively good industrial application value is achieved.