The Development of PGD

This chapter will cover the following topics: Introduction Why develop PGD? The impetus for its development Research progress that made it possible Legislation—the Warnock report Early steps towards PGD Sexing of embryos by DNA amplification FISH comes into its own Mosaicism and the extent of aneuploidy—implications for PGD Aneuploidy screening begins First single gene diagnosis First cancer gene PGD Development of single cell CGH for comprehensive chromosome analysis PGS gets a bad name Application of metaphase CGH Development of array CGH and its application for PGS to select ‘the single euploid embryo’.