Effect of black and white sesame on lowering blood lipids of rats with hyperlipidemia induced by high-fat diet

Abstract Sesamum indicum has various biological effects, and this study aimed to investigate its hypolipidemic effect. A hyperlipidemia rat model was established by feeding rats with high-fat diets in this study, then the hyperlipidemia rats were fed with different doses of black and white sesame seeds and black and white sesame kernels. The serum and liver biochemical indicators of the rats were determined, and liver pathology analysis was conducted to evaluate the hypolipidemic effect of sesame. The results showed that the blood lipid of SD rats fed with high-fat diet for three weeks was higher than 200 mg/dL, indicating that the hyperlipidemia rat model was successfully established. At the same dose, the final body weights of the rats of white sesame seed and kernel groups were higher than those of the black sesame seed and kernel groups; and the weights of the black and white sesame seed groups were lower than those of the black and white sesame kernel groups. The liver indexes of the normal control group and the experimental groups were significantly lower than the model control group (P  C), glutathione peroxidase (GSH-Px) and total superoxide dismutase (T-SOD) in the liver of each experimental group were significantly higher than those in the model control group (P